Abstract: Liposomal Based Delivery System for Intralesional Bleomycin in the Treatment of Keloids and Hypertrophic Scars
نویسندگان
چکیده
INTRODUCTION: Many studies have proved the role, efficacy and safety profile of intralesional bleomycin in the management of hypertrophic scars and keloids.1 Liposomes, by virtue of their lipid bilayer, have potential to enhance the delivery of drug to the desired area. Drugs encapsulated in liposomes are expected to be transported without rapid degradation and minimum side effects to the recipients.2 Hence, the permeability of the drug to the cell is increased many folds. Combining this property of liposomes with the intralesional injection of Bleomycin, we conducted a study to assess whether the effect of bleomycin can be augmented by liposomal delivery system.
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Abstract: Outcome Study after Nasal Alar Subunit Reconstruction: Comparing Paramedian Forehead Flap to Nasolabial Flap
INTRODUCTION: Many studies have proved the role, efficacy and safety profile of intralesional bleomycin in the management of hypertrophic scars and keloids.1 Liposomes, by virtue of their lipid bilayer, have potential to enhance the delivery of drug to the desired area. Drugs encapsulated in liposomes are expected to be transported without rapid degradation and minimum side effects to the recip...
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BACKGROUND Cryotherapy combined with intralesional triamcinolon injection is the most common traditional therapy for hypertrophic scars and keloids. The literature contains few articles on the use of bleomycin tattoo for treatment of these conditions. OBJECTIVE This study compares the efficacy of bleomycin tattoo with that of cryotherapy combined with intralesional triamcinolon injection for ...
متن کاملHypertrophic scars and Keloids
The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the ...
متن کاملHypertrophic scars and Keloids
The available treatment modalities for hypertrophic scars and keloids have very little success. Surgical treatment of these lesions without adjuvant therapy is also associated with high recurrence rate. Hypertrophic scars and keloids are the results of a series of cellular and molecular changes which their identification can guide us toward new treatment modalities which may decrease the ...
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Keloid scars are often considered aesthetically unattractive and frustrating problems that occur following injuries. They cause functional and cosmetic deformities, displeasure, itching, pain, and psychological stress and possibly affect joint movement. The combination of these factors ultimately results in a compromised quality of life and diminished functional performance. Various methods hav...
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